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KMID : 0608320090160020041
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Physical Therapy Korea
2009 Volume.16 No. 2 p.41 ~ p.49
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Effects of Low and Moderate Intensity Treadmill Exercise on Functional Recovery and Histological Changes After Spinal Cord Injury in the Rats
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Kim Gi-Do
Kim Gye-Yeop
Kim Eun-Jung
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Abstract
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This study was designed to investigate the effects of treadmill exercise of low-intensity and moderate- intensity on the functional recovery and histological change in spinal cord injury (SCI) rats. SCI was induced by the spinal cord impactor dropped after laminectomy. Experimental groups were divided into the Group Ⅰ (normal control), Group Ⅱ (non-treatment after SCI induction), Group Ⅲ (low-intensity treadmill exercise after SCI induction), Group Ⅳ (moderate-intensity treadmill exercise after SCI induction). After operation, rats were tested at modified Tarlov scale at 2 days with divided into 4 groups, and motor behavior test (BBB locomotor rating scale, Grid walk test) was examined at 3, 7, 14, and 21 days. For the observation of damage change and size of the organized surface in spinal cord, histopathological studies were performed at 21 days by H & E, and BDNF(brain-derived neutrophic factor) & Trk-b immunohistochemistry studies were performed at 1, 3, 7, 14, 21 days. According to the results, treadmill exercise can play a role in facilitating recovery of locomotion following spinal cord injury. Specially, moderate-intensity treadmill exercise after SCI induction was most improvement in functional recovery and histological change.
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KEYWORD
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Histological change, Locomotor behavioral test, Spinal cord injury, Treadmill exercise
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